CO2 laser versus cold steel margin analysis following endoscopic excision of glottic cancer

Citations of this article
Mendeley users who have this article in their library.

This article is free to access.


Objective: To compare the suitability of CO2 laser with steel instruments for margin excision in transoral laser microsurgery. Methods: Prospective randomized blinded study. Patients with glottic cancer undergoing laser resection were randomized to margin excision by either steel instruments or CO2 laser. Margins were analyzed for size, interpretability and degree of artifact by a pathologist who was blinded to technique. Results: 45 patients were enrolled in the study with 226 total margins taken. 39 margins taken by laser had marked artifact and 0 were uninterpretable. 20 margins taken by steel instruments had marked artifact, and 2 were uninterpretable. Controlling for margin size, the laser technique was associated with increasing degrees of margin artifact (p = 0.210), but there was no difference in crude rates of uninterpretability (p = 0.24). Conclusion: Laser margin excision is associated with a greater degree of artifact than steel instrument excision, but was not associated with higher rate of uninterpretability. © 2014 Makki et al.

Author supplied keywords




Makki, F. M., Rigby, M. H., Bullock, M., Brown, T., Hart, R. D., Trites, J., … Taylor, S. M. (2014). CO2 laser versus cold steel margin analysis following endoscopic excision of glottic cancer. Journal of Otolaryngology - Head and Neck Surgery, 43(FEB).

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free