Effects of Bee Bread on Serum Lipid Profile in Alloxan Induced Diabetic Female Rats

Abstract

Introduction: Diabetes Mellitus (DM) represents one of the most frequent public health problems with increasing prevalence worldwide. This condition is caused by increased hepatic glucose production, lower insulin secretion, and impaired insulin action. Subsequently, the lipid is used as an alternative resource of cellular energy, resulting in abnormalities of lipid metabolism. Aim: To determine effects of Bee Bread on Serum Lipid Profile in Alloxan Induced Diabetic rats Methodology: A total thirty female Sprague-Dawley rats were grouped in to five. Gp1: Non-DM, Gp2: DM Naïve, Gp3: DM + 200BB, Gp4: DM + 400BB and Gp5: DM + Metformin. Animals were induced with DM following single injection of freshly prepared alloxan in normal saline. Animals were treated for three weeks before they were sacrificed using chloroform sedation. Blood samples were collected for Serum Lipid Profile analysis. Results: When compared, Serum TC, TG, and LDL-C were significantly higher in the DM group compared to Non-DM, BB administered and DM + Metformin groups. Reduction in these lipids was achieved with the administration of Bee Bread. HDL-C was significantly lower in the DM group, compared to other groups. The study revealed improvements in serum HDL-C with the administration of Bee Bread. Conclusion: Bee Bread causes reduction in lipids and improves HDL-C in Diabetic Rats.