Schiff base-Cyclodextrins inclusion complexes

Abstract

A Schiff base derived from the condensation ofr indole-3-carboxaldehyde with sulfathiazole wase prepared, and used to prepare three inclusion complexes with β-CD, 2HP-β-CD and 2HP-γ-CD by freeze drying method, the formation of Schiff base and the nature of interaction with CDs were confirmed by IR, HNMR and XRD. The phase solubility of Schiff base in β-CD and 2HP-β-CD were studied following Higuchi and Connors method, the stability constant value of complexes and the solubilization efficiency were estimated.