Synthesis and characterization of some N-substituted amides of salicylic acid

Abstract

The synthesis of some N-substituted aromatic amides in the salicylic acid series was achieved, by direct reaction between primary amines and salicylic acid in inert organic solvent, in the presence of PCl3. The compounds that were obtained, partially not described in literature, were characterized by chemical-physical methods.Salicilna kiselina, odnosno njeni supstituisani aromaticni amidi upotrebljavaju se kao dezinfekciona sredstva, antifungicidi, antimikotici i kao antibakterijske supstance u humanoj i veterinarskoj medicini, u razlicitim industrijskim sektorima i u poljoprivredi. U radu su date sinteze nekih N-supstituisanih aromaticnih amida salicilne kiseline, reakcijom izmedju primarnih amina i salicilne kiseline u internim organskim rastvaracima i u prisustvu PCl3. Dobijeni derivati okarakterisani su fizicko-hemijskim metodama pri cemu su dati njihova molekulska forma, masa i elementarni sastav.