6-gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids a, b and c, three new monoacyldigalactosylglycerols, from zingiberis rhizoma originating in taiwan

Abstract

By monitoring the effects on HCI / ethanol-induced gastric lesions in rats, a new anti-ulcer principle named 6-gingesulfonic acid was isolated from Zingiberis Rhizoma, the dried rhizome of Zingiber officinale roscoe (cultivated and processed in Taiwan) together with three new monoacyldigalactosylglycerols named gingerglycolipids A,B and C. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. 6-Gingesulfonic acid showed more potent anti-ulcer activity than 6-gingerol and 6-shogaol. © 1992, The Pharmaceutical Society of Japan. All rights reserved.