Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome

Abstract

Background: Human pyrin is an important regulator of inflammation and is involved in the pathogenesis of familial Mediterranean fever (FMF). Results: Ribotoxic stress activates the human pyrin inflammasome. Conclusion: p38 MAPK signaling is required for assembly of the human pyrin inflammasome. Significance: Understanding the mechanism of activation of the pyrin inflammasome is crucial for the development of therapeutics to treat FMF. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.