Pseudoatrophy of the Brain with Valproic Acid Monotherapy

Abstract

A patient is described who, while on valproic acid monotherapy, developed reversible shrinkage of the brain, documented by computerized tomography with associated cognitive deficit. Although pseudoatrophy has been reported with steroid therapy, this is the first implication of an anticonvulsant drug in the etiology of that condition. © 1987, Canadian Neurological Sciences Federation. All rights reserved.