Abstract
Objective: To investigate whether hydrocortisone supplementation increases blood pressure and decreases inotrope requirements compared with placebo in cooled, asphyxiated neonates with volume-resistant hypotension. Study design: A double-blind, randomized, placebo-controlled clinical trial was conducted in a Level III neonatal intensive care unit in 2016-2017. Thirty-five asphyxiated neonates with volume-resistant hypotension (defined as a mean arterial pressure [MAP]
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Kovacs, K., Szakmar, E., Meder, U., Szakacs, L., Cseko, A., Vatai, B., … Jermendy, A. (2019). A Randomized Controlled Study of Low-Dose Hydrocortisone Versus Placebo in Dopamine-Treated Hypotensive Neonates Undergoing Hypothermia Treatment for Hypoxic−Ischemic Encephalopathy. Journal of Pediatrics, 211, 13-19.e3. https://doi.org/10.1016/j.jpeds.2019.04.008
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