Histological Effects of Alcoholic Extract of Cnidoscolus Aconitifolius on Bone Marrow Biopsy in Adult Male Wistar Rats

Abstract

Histological Effects Of Alcoholic Extract Of Cnidoscolus Aconitifolius On Bone Marrow Biopsy In Adult Male Wistar Rats.The present study was designed to investigate the effect of alcoholic extract of Cnidoscolus aconitifolius on bone marrow biopsy. The rats were acclimatized for two weeks, weighed and sorted into four groups (A - D) of three animals each with corresponding weights in the same group. Alcoholic extract of Cnidoscolus aconitifolius was administered orally to each animal in groups B – D at 200ml/kg, 300ml/kg and 500ml/kg respectively. Group A was the control group and they fed with animal feed and water liberally. At the end of administration, animals were sacrificed and the bone marrow biopsy obtained from the xiphoid process of the sternum. This product was fixed in 10% formol saline and stained using hematoxylin and eosin.Results showed a marked dose dependent distortion of bone marrow histologic architecture.