A master CLOCK hard at work brings rhythm to the transcriptome

Abstract

In this issue of Genes & Development, Abruzzi et al. (pp. 2374-2386) use chromatin immunoprecipitation (ChIP) tiling array assays (ChIP-chip) to show that physical interactions between circadian (≅24-h) clock machineries and genomes are more widespread than previously thought and provide novel insights into how clocks drive daily rhythms in global gene expression. © 2011 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/11.