Abstract
The general method for the tandem phosphination-decarboxylation-oxidation of alkynyl acids under aerobic conditions has been developed. In the presence of CuSO4·5H2O and TBHP, the reactions provide a novel access to β-ketophosphine oxides in good to excellent yields. This transformation allows the direct formation of a P-C bond and the construction of a keto group in one reaction.
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CITATION STYLE
Zhang, P., Zhang, L., Gao, Y., Xu, J., Fang, H., Tang, G., & Zhao, Y. (2015). Copper-catalyzed tandem phosphination-decarboxylation-oxidation of alkynyl acids with H-phosphine oxides: A facile synthesis of β-ketophosphine oxides. Chemical Communications, 51(37), 7839–7842. https://doi.org/10.1039/c5cc01904d
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