Natural phyto-active antihyperglycemic moieties as preventive therapeutics for diabetes type II

Abstract

Diabetes mellitus type II (DM II) is a state characterized by hyperglycemia as fallout of endocrine dysfunction. This condition comes under the category of lifestyle diseases. The impaired insulin secretion, resistance or a combination of both results in the dysregulation of carbohydrate, protein and lipid metabolism. The extremities of this state are associated with other detrimental complications such as cardiomyopathy, retinopathy, nephropathy, hepatopathy and neuropathy etc. DM II has now become a growing epidemic and a major health concern globally. Naturopathy deals with the development of promising therapeutics using herbal origin to ensure minimal or no other side effects with best efficacy of the drug as a promising candidate against a diseased condition. Therefore the review aims to find out a range of medicinal plants that can be used as a natural remedy for the management of DM II, through isolation of active plant moieties (specifically proteins) with antihyperglycemic properties. The active plant metabolites, with antidiabetic potential based on the available pharmacological reports are used as herbal cure against DM II. These isolated active plant moieties, possessing antihyperglycemic properties, might play a significant role in the development of a formulation of plant protein moieties (as a preventive therapeutic) to reduce the prevalence of DM II and to serve the mankind.