Abstract
Rhythmic heartbeats are paced by electrical impulses that are autonomously generated by cardiac pacemaker cells. This chapter briefly summarizes our recent findings regarding the embryonic origin of and molecular mechanism delineating cardiac pacemaker cells, showing that pacemaker cells are physically segregated and molecularly programmed, in a tertiary heart field, prior to the onset of cardiac morphogenesis.
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Bressan, M., Liu, G., Louie, J. D., & Mikawa, T. (2016). Cardiac pacemaker development from a tertiary heart field. In Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology (pp. 281–288). Springer Japan. https://doi.org/10.1007/978-4-431-54628-3_39
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