FORMULATION AND EVALUATION OF RAPID RELEASE SYSTEM OF IRBESARTAN BY LIQUISOLID TECHNOLOGY

Abstract

The oral route is still the most popular way to administer drugs since it is convenient, patient compliance is high, and the cost of producing medicine is low. A medication needs to dissolve in the stomach juices in order to be absorbed into the systemic circulation after oral delivery. Poor solubility is thus one of the main obstacles facing medication development today. The solubility and dissolution rate of hydrophobic medicines, which are classified as class II in the biopharmaceutics categorization system, limit their bioavailability. Reducing particle size, reducing crystallinity, and/or increasing surface area can all help these medications dissolve more quickly. Numerous investigations have been conducted in an effort to produce nanoparticles and microparticles, which reduce particle size and speed up the dissolving of medications. However, due to the presence of the residual solvent in the drug formulation, it is disadvantageous to use toxic solvents. To overcome the problem, the technique of “liquisolid compacts” is a new and promising approach towards dissolution enhancement Liquisolid compacts possess acceptable flowability and compressibility properties.The in vitro release studies revealed that the liquisolid tablets showed a faster drug release compared to the conventional tablets. Keywords: Solubility, tablet, liquisolid, dissolution, microparticles