Detection of malignant tissue using metal dielectric interface based plasmonic biosensor

Abstract

Metal-dielectric interface based Plasmonic biosensors commonly known as Surface Plasmonic Resonance (SPR) used in numerous applications in the analysis of bio reagents interaction and detection of the biological pathogen, cells and provides the advantage of real-time label-free efficient method. Sensitivity is a key parameter to measure sensor performance during development. Among all the plasmonic configurations, waveguide coupled configuration is most effective. In such a configuration an SPR and a waveguide are coupled through an evanescent field. This provides superior control over the biological reagent interaction, greater sensitivity and a multichannel-robust sensing device. Such devices are very small in size, lightweight as compared to prism coupled configuration which is bulky. These devices are also equipped to segregate specific sensor responses from non-specific response simultaneous multi analytes analysis. In view of the aforesaid benefits of waveguide coupled SPR, our present work focuses on a dual channel integrated optical waveguide based on metal dielectric interface biosensor. To study the behaviour of a waveguide coupled SPR sensor, we carried out analysis and simulation of SPR on multilayer geometries using tumour-associated antigens (TAAs). First, we started with the analysis of an SPR in the multi-layer intersection and observed the effect of variation of material characteristics on SPR profile. Further, extended our investigation to multilayered optical waveguide and the propagation constant was calculated. TAA and Newton’s method were used for Lung Cancer and Breast Cancer infected tissue and sensitivity 300nm/RIU obtained.