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Improvement of L-lactate production by CYB2 gene disruption in a recombinant Saccharomyces cerevisiae strain under low pH condition

Bioscience, Biotechnology and Biochemistry (2008) 72(11) 3063-3066
DOI: 10.1271/bbb.80493
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Abstract

Using a DNA microarray, we found that expression of the genes related to lactate metabolism was upregulated in a lactate-producing recombinant Saccharomyces cerevisiae strain. Disruption of the CYB2 gene encoding L-lactate dehydrogenase improved the L-lactate production by S. cerevisiae under low pH condition.

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Ookubo, A., Hirasawa, T., Yoshikawa, K., Nagahisa, K., Furusawa, C., & Shimizu, H. (2008). Improvement of L-lactate production by CYB2 gene disruption in a recombinant Saccharomyces cerevisiae strain under low pH condition. Bioscience, Biotechnology and Biochemistry, 72(11), 3063–3066. https://doi.org/10.1271/bbb.80493

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