Cytogenetic damage in turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms

Abstract

The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasinblocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the infl uence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure signifi cantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our fi ndings need to be verifi ed in future studies with a larger sample.