Automatic calculation of myocardial perfusion reserve using deep learning with uncertainty quantification

Abstract

Background: Myocardial perfusion reserve index (MPRI) in magnetic resonance imaging (MRI) is an important indicator of ischemia, and its measurement typically involves manual procedures. The purposes of this study were to develop a fully automatic method for estimating the MPRI and to evaluate its performance. Methods: The method consisted of segmenting the myocardium in dynamic contrast-enhanced (DCE) myocardial perfusion MRI data using Monte Carlo dropout U-Net, dividing the myocardium into segments based on landmark localization with machine learning, and estimating the MPRI after the calculation of the left ventricular and myocardial contrast upslopes. The proposed method was compared with a reference method, which involved manual adjustments of the myocardial contours and upslope ranges. Results: In test subjects, MPRIs measured by the proposed technique correlated with those by the manual reference in segmental assessment [intraclass correlation coefficient (ICC) =0.75, 95% CI: 0.70–0.79, P<0.001]. The automatic and reference MPRI values showed a mean difference of −0.02 and 95% limits of agreement of (−0.86, 0.82). Conclusions: The proposed automatic method is based on deep learning segmentation and machine learning landmark detection for MPRI measurements in DCE perfusion MRI. It holds the potential to efficiently and quantitatively assess myocardial ischemia without any user’s interaction.