Abstract
Under carbonylative conditions, neutral Rh(I)-systems modified with weak donor ligands (AsPh3 or 1,4-oxathiane) undergo N-Cbz, N-benzoyl, or N-Ts directed insertion into the proximal C-C bond of aminomethylcyclopropanes to generate rhodacyclopentanone intermediates. These are trapped by N-tethered alkenes to provide complex perhydroisoindoles.
Cite
CITATION STYLE
Wang, G. W., McCreanor, N. G., Shaw, M. H., Whittingham, W. G., & Bower, J. F. (2016). New Initiation Modes for Directed Carbonylative C-C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes. Journal of the American Chemical Society, 138(41), 13501–13504. https://doi.org/10.1021/jacs.6b08608
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