The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study

Abstract

Background: Human growth factors serve as secretomes that regulate skin cell proliferation/differentiation and production of extracellular elements of the matrix and treat photo-aging. Micro-needling of skin can also improve aging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmetic benefits. Objectives: This open, randomized split-face and single-center controlled study evaluated the safety and efficacy of the application of a cosmeceutical formulation, which incorporated growth factors derived from cultured pluripotential stem cells of unfertilized human ovum, in the treatment of photo-damaged facial skin. The use of micro-needling to stem cell-treated skin was evaluated for additional benefit. Material and Methods: Ten subjects in Group 1 with mild-to-moderate photo-damaged skin received the growth factor emulsion to one side of the face and serum to the eyelids/periorbitum and placebo on the contralateral side for twelve (12) weeks. Ten subjects in a separate Group 2 with similar photodamaged skin received the same growth factor emulsions and serum to both sides of the face and eyelids/periorbitum, but only one side was treated with four micro-needling procedures four weeks apart. Subjects in Group 1 were assessed at baseline, 6 weeks and 12 weeks with the Canfield VISIA Investigator System and standardized 2D photography. Subjects in Group 2 were similarly assessed with the addition of the DermaLab Cortex System. Data analysis compared the p-values with the alpha level for statistical difference. Results: Group 1 subjects demonstrated a beneficial effect by VISIA Analysis on reduction of pigmented spots, UV-light damage with more effective effacement of wrinkles and textural changes after three months compared with that observed on the placebo side.