Synthesis and biological activity of some 4-5-alkyl- Or 5-aryl-2-furfuryudene-1,3-disubstituted-2-pyrazolin-5-ones

Abstract

A series of N-substituted-3-methyl-4-(5-alkyl- or 5-aryl-2-furfurylidene)-2-pyrazolin-5-ones(7-9)a-c have been synthesised by the reaction of N-substituted-3-methyl-2-pyrazolin-5-ones 6a-c with 5-alkyl-or 5-aryl-2-furfuraldehyde. The compounds were evaluated for their antibacterial activity against both Gram-positive and Gram-negative bacteria.