6-Keto PGE: A possible metabolite of prostacyclin having platelet antiaggregatory effects

Abstract

Hepatic metabolism of prostacydin (PGI,) results in the formation of several biologically inactive lipids and one stable product that has the same chromatographic and biological properties as authentic 6-keto PGE,. Both prostaglandins, 6-keto PGE, and PGI2, hare comparable potency in their antiaggregatory and disaggregatory effects on platelets. They contract the superfused rat stomach strip but differ in their effects on the bovine coronary artery, which is contracted by 6-keto PGE, but relaxed by PGI2. Further, 6-keto PGE, is considerably more stable than PGI,. Thus, 6-keto PGE, could account for some of the prolonged effects occasionally seen with PGI © 1980 American Heart Association, Inc.