Modulation of Pimpinella tirupatiensis aqueous extract on Brain Mitochondrial Enzymes in STZ induced diabetic rats

Abstract

The objective of the present study was to investigate the role of Pimpinella tirupatiensis (Pt) aqueous extract on brain mitochondrial enzymes in Streptozotocin (STZ) induced diabetic rats. Adult male wistar strain rats were divided into five groups as NC (normal control), Pt. (Pimpinella treatment), DC (Diabetic control), D+Pt (Diabetic+ Pimpinella treatment), D+Gli (Diabetic + Glibenclamide treatment). Treatment was given as per the experimental protocol for 30days. Succinate dehydrogenase (SDH), glucose-6-phosphate dehydrogenase (G6PD), malate dehydrogenase (MDH),and glutamate dehydrogenase (GDH), and lactae dehydrogenase (LDH) enzymes activities were assayed in the brain tissue. In diabetic rats, we observed decreased activities of SDH, G6PDH, MDH, GDH and increased LDH activity. However with the Pimpinella tirupatiensis treatment mitochondrial enzymes activities were came back to normalcy. Our results suggest that the Pt supplementation modulates the mitochondrial enzymes activities in diabetic rats.