Effects of organoantimony(III) compounds of sterically hindered bifunctional tetradentate ligands on the reproductive system of male rats

Abstract

The antifertility activity of organoantimony(III) complexes PhSb[RC(NC6H4S)CH2(NC6H4S )CR′] {R = R′ = CH3 (R1) and R = R′ = CF3 (R2)} derived from corresponding sterically hindered bifunctional tetradentate ligands in the male rats was determined. The administration of compounds R1 and R2 at the dose level of 20 mg/kg. b. wt. significantly reduced the weights of testes and epididymides. Auxiliary glands showed a significant reduction after the treatment of compound R1 only. Treated animals showed a notable depression of spermatogenesis. The preleptotene spermatocytes were decreased by 76.19 and 47.06; the secondary spermatocytes by 87.4% and 54.8% and the step-19 spermatids by 72.9 and 46.77% respectively, following the compound R1 and R2 treatment. Reduced sperm count and motility resulted in 100% negative fertility in both the treated groups. A significant fall in the content of various biochemical parameters of reproductive tissues was observed after R1 and R2 treatment in comparison to controls.