Blood Pressure-Lowering Effect of Extract from Lactobacillus casei in Spontaneously Hypertensive Rats (SHR)

Abstract

The effects of oral administration of hot water extract from autologous lysate of Lactobacillus casei (LEx) on the systolic blood pressure (SBP) were studied in spontaneously hypertensive rats (SHR). Oral doses of 10 mg/kg of LEx produced a significant decrease of the SBP of SHR, but LEx had no effect in normotensive rats. The long-term administration of LEx (1 or 10 mg/kg/day) to SHR from 5 to 17 weeks after birth suppressed the development of hypertension. LEx dialysed against distilled water was separated into a polysaccharide fraction (SG-1), a protein fraction (PR-1), and a nucleic acid fraction (NA-1), and SBP-lowering effects of these materials were investigated in SHR at the same dose (10 mg/kg). The most effective material of these three was SG-1. © 1990, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.