A case of acute renal failure after intermittent rifampicin therapy

Abstract

This report presents a 49 years-old Japanese woman who suffered from acute renal failure after intermittent administration of rifampicin. She was diagnosed as lepromatous leprosy at April 1949. She was administrated with promin and DDS after the admission to the sanatorium. DDS was discontinued between January 1981 and October 1981, because her bacterial index was kept negative. At October 1981, exanthema appeared on her face, and diagnosed as relapse of leprosy. Since 2 November 1981, she has been given DDS from 50 mg to 75 mg daily and rifampicin from 150 mg to 450 mg daily. But rifampicin therapy was stopped 5 times in the period from 2 November 1981 to 16 August 1983, because swelling of extremities and face, face-ache, iritis of left eye and left drop foot developed. An oliguria appeared at 15 August 1983, and at the morning of 16 August, an anuria with high fever, head-ache, nausea and edema on her face appeared suddenly.