Monosomy 12 and deletion of 13q34 in a case of chronic lymphocytic leukemia with concomitant lung cancer

Abstract

Background. We described a patient with chronic lymphocytic leukemia (CLL) and lung cancer and unusual chromosomal aberrations. Case report. At the same time with the diagnosis of B-cell CLL, squamocellular lung carcinoma diagnosis was established. Using interphase fluoresecence in situ hybridization technique (FISH) we detected monosomy 12 and deletion of 13q34 occured in the same clone. One month after the beginning of examination the patient died unexpectedly during sleep immediately before we applied a specific treatment for CLL or lung carcinoma. Conclusion. Simultaneous occurrence of monosomy 12 and deletion of 13q34 in a patient with B-cell CLL has been described only once before, but as a part of a complex karyotype. The prognostic significance of these abnormalities remains uncertain.Uvod. U ovom radu opisali smo slucaj bolesnika sa Bcelijskom hronicnom limfocitnom leukemijom (HLL) i karcinomom pluca kod koga je detektovana neuobicajena hromozomska abnormalnost. Prikaz bolesnika. U isto vreme, kada je kod bolesnika postavljena dijagnoza HLL, dijagnostikovan je i skvamocelularan karcinom pluca. Koriscenjem tehnike fluorescentne in situ hibridizacije (FISH) dokazano je postojanje monozomije 12 i delecije 13q34 u istom klonu. Mesec dana nakon pocetka ispitivanja bolesnik je iznenada umro u snu pre primene bilo kakvog terapijskog modaliteta. Zakljucak. Simultana pojava monozomije 12 i delecije 13q34 kod bolesnika sa B-HLL do danas je objavljena samo jednom i to kao deo kompleksnog patoloskog kariotipa. Prognosticki znacaj ovih aberacija jos uvek je nepoznat.