Decreased Cystathionine-γ-lyase (CSE) Activity in Livers of Type 1 Diabetic Rats and Peripheral Blood Mononuclear Cells (PBMC) of Type 1 Diabetic Patients

Abstract

Background: Mechanism of impaired H2S signaling in diabetes is not clear. Results: Livers from type 1 diabetic (T1D) rats and PBMC isolated from T1D patients have lower cystathionine-γ-lyase activity. High glucose and/or high ketone treatment also decreased cystathionine-γ-lyase activity in U937 monocytes and PBMC of healthy subjects. Conclusion: Uncontrolled glycemia and ketosis down-regulate cystathionine-γ-lyase activity in T1D. Significance: Impaired cystathionine-γ-lyase can dysregulate H 2S signaling in diabetes. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.