In vitro antibacterial activity of dithiocarbamate organotin(IV) complexes towards Staphylococcus aureus

Abstract

The complexes [Sn{S2CN(CH2)4} 2Cl2], 1, [Sn{S2CN(CH2) 4}2Ph2] {Ph=phenyl}, 2, [Sn{S 2CN(CH2)4}Ph3], 3, [Sn{S 2CN(CH2)4}2n-Bu2] {n-Bu=n-butyl}, 4, [Sn{S2CN(C2H5) 2}Cy3] {Cy=Cyclohexyl}, 5, [Sn{S2CN(C 2H5)2}2Cl2], 6, [Sn{S 2CN(C2H5)2}2Ph 2], 7, [Sn{S2CN(C2H5) 2}Ph3], 8, [Sn{S2CN(C2H 5)2}3Ph], 9 and [Sn{S2CN(C 2H5)2}Cy3], 10 were used in this work. The in vitro antibacterial activity study was performed against Staphylococcus aureus (ATCC 25923) and all complexes were active. The activity was measured in terms of inhibition zones (mm) and minimum inhibitory concentration test, MIC (μg mL-1). In terms of inhibition zones compounds 6 and 9 presented the best results. Complexes where the -SnPh 3 moiety is present possess the smaller MIC values. The apparent contradiction of the tests might be related to diffusion properties of the organotin complexes.