The Serum Levels of Malondialdehyde, Vitamin E and Erythrocyte Catalase Activity in Psoriasis Patients

Abstract

BACKGROUND Psoriasis is a common skin disease which is characterized by increased epidermal proliferation and dermal inflammation affecting 0.1-3% of general population. Most of the psoriasis patients are young or middle aged adults, although no age exempted. The oxidative stress develops due to imbalance in oxidants and antioxidants, which was proposed to have role in psoriasis. AIMS AND OBJECTIVES The presented research work was planned to evaluate oxidative stress by measuring serum malondialdehyde (MDA) as oxidant and serum vitamin E, erythrocyte catalase (CAT) activity as antioxidants in psoriasis patients. MATERIALS AND METHODS Total 90 clinically diagnosed psoriasis patients of age group of 20 to 60 years and without any drug therapy for preceding two months and 90 matched healthy controls were included in the presented study. The severity of psoriasis was determined by PASI score. The fasting blood sample collected and accessed for serum MDA, serum vitamin E and erythrocyte catalase activity. RESULTS The study results were compiled and statistical analysis was done using students t-test. Our results showed significantly increased levels of serum MDA (p<0.001) and significantly decreased serum vitamin E (p<0.001) as well as erythrocyte catalase activity (p<0.001) in psoriasis patients as compared to controls. CONCLUSION The presented study concluded the oxidative stress in psoriasis, indicated by increased serum MDA and decreased Vitamin E, erythrocyte catalase activity. Our study also supports the possibility of involvement of oxidative stress in pathogenesis of psoriasis.