Abstract
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2-1306T and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9-1562C>T was not. Tumour MMP levels were not determined by their SNP genotypes. © 2008 Cancer Research.
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Langers, A. M. J., Sier, C. F. M., Hawinkels, L. J. A. C., Kubben, F. J. G. M., Van Duijn, W., Van Der Reijden, J. J., … Verspaget, H. W. (2008). MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. British Journal of Cancer, 98(11), 1820–1823. https://doi.org/10.1038/sj.bjc.6604380
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