Left ventricular dysfunction in patients with angina pectoris, normal epicardial coronary arteries, and abnormal vasodilator reserve

Abstract

Thirty-three patients with chest pain despite angiographically normal coronary arteries underwent both coronary flow studies during pacing and resting and exercise gated blood pool scintigraphy. During atrial pacing after administration of ergonovine, those patients developing their typical chest pain demonstrated significantly lower great cardiac vein flow (97 ± 31 vs 150 ± 33 ml/min, p < .005) and a higher left ventricular end-diastolic pressure after pacing (20 ± 4 vs 12 ± 1, p < .001) compared with those without pain and in the absence of significant luminal narrowing of the epicardial coronary arteries. The 26 patients with abnormal vasodilator reserve demonstrated reduced left ventricular ejection fraction during exercise (58 ± 8%) compared with the seven patients with appropriate vasodilator reserve (66 ± 4%, p < .05) and with a group of 52 control patients of similar age and sex distribution and free of known heart disease (66 ± 10%, p < .005). Thus, patients with chest pain resulting from abnormal vasodilator reserve demonstrate abnormalities of left ventricular systolic and diastolic function suggestive of myocardial ischemia.