Survival and clinical features in Hispanic amyotrophic lateral sclerosis patients

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The demography, survival, and motor phenotypes of amyotrophic lateral sclerosis (ALS) patients have been rarely described in Hispanic countries. The clinical characteristics and survival of a series of Mexican ALS patients are described. Mexican patients with definite ALS were included in a five-year retrospective longitudinal study. Their demographic and clinical features, cumulative survival rates, and independent predictive factors for survival were analysed. Sixty-one definite ALS patients were included. The median follow-up period was 35 months (range 12-108 months). Males were predominant (1.8: 1), the mean age at onset was 47.5 ± 10.5 years, and the median interval from onset to diagnosis was 12 months. Spinal onset occurred in 66% of patients. Upper motor neuron phenotype was predominant in 53% of patients. The overall mean survival from onset was 68.6 months, and from diagnosis was 57.8 months. Longer survival was determined in patients aged ≤ 40 years (54.7 months) compared with other age groups (p = 0.006). In conclusion, the clinical heterogeneity, male predominance, and survival rates in our sample are consistent with those of other studies. Patients in this series had a younger age at onset and a clear trend toward longer survival compared with those of other population studies. © 2011 Informa Healthcare.




Martínez, H. R., Molina-López, J. F., Cantú-Martínez, L., González-Garza, M. T., Moreno-Cuevas, J. E., Couret-Alcaraz, P., … Hernandez-Torre, M. (2011). Survival and clinical features in Hispanic amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis, 12(3), 199–205.

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