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Isolation and structural determination of makinolide b from Streptomyces sp. MK-19

Bioscience, Biotechnology and Biochemistry (2013) 77(9) 1964-1966
DOI: 10.1271/bbb.130204
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Abstract

A new 16-membered macrolide named makinolide B (1) was isolated from Streptomyces sp. MK-19. The structure of makinolide B (1) was determined on the basis of 2D NMR experiments involving DQF-COSY, TOCSY, HSQC, and HMBC methods. Application of the paper disk diffusion method to makinolide B (1) showed weak antibacterial activity against Staphylococcus aureus at the dose of 100μg/disk.

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Hidaki, M., Yoshida, M., Ogawa, N., & Kodani, S. (2013). Isolation and structural determination of makinolide b from Streptomyces sp. MK-19. Bioscience, Biotechnology and Biochemistry, 77(9), 1964–1966. https://doi.org/10.1271/bbb.130204

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