A systematic review of the association between pulmonary tuberculosis and the development of chronic airflow obstruction in adults

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a major public health concern, accounting for 3 million deaths annually, 90% of which occur in low-and middle-income countries. Pulmonary tuberculosis (PTB) as a contributory factor in the aetiology of COPD is under debate, with most epidemiologic evidence suggesting a positive association. Objectives: To compile a systematic review of evidence for an association between PTB and the development of chronic airflow obstruction (CAO). Methods: We performed a systematic review of original English-language, peer-reviewed literature using the PubMed/MEDLINE database. CAO was defined by spirometry [FEV1:FVC ratio <0.70 or