Pin1 flips Alzheimer's switch.

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Abstract

The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.

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Etzkorn, F. A. (2006). Pin1 flips Alzheimer’s switch. ACS Chemical Biology. https://doi.org/10.1021/cb600171g

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