Genetic variability analysis in a population from Bogota: Toards a haplotype map

Abstract

Introduction: The HapMap and the 1000 Genomes projects have been important for understanding the genetic component of common diseases and normal phenotypes. However, the Colombian genetic variability included in these projects is not fully representative of our country. Objective: To contribute to the knowledge of the Colombian genetic variability through the genomic study of a sample of individuals from Bogota. Materials and methods: A total of 2,372,784 genetic markers were genotyped in 32 individuals born in Bogota whose parents are from the same region, using the Illumina™ platform. The genetic variability levels were determined and compared with the data available from other populations of the 1000 Genomes Project. Results: The genetic variability detected in the individuals from Bogota was similar to those with shared ancestry. However, despite the low levels of genetic differentiation between Bogota and Medellin, populations the principal component analysis suggested a different genetic composition in them. Conclusions: Our genomic analysis of a Bogota sample allowed us to detect similarities and differences with other American populations. The increase of the Bogota sample and the inclusion of samples from other regions of the country will improve our understanding of the genetic variability in Colombia, essential for studies of human health and the prevention and treatment of common diseases in our country.