Synthesis of

Abstract

Biologically interesting 9(O)-methano-Δ6-prostaglandin I1 (9(0)-methano-Δ6-PGI1), a chemi-cally stable analog of prostacyclin (PGI2), was efficiently synthesized from 1,3-cyclooctadiene with high stereo- and regiochemical control. In all three biological test systems examined, 9(O)-meth-ano-Δ6-PGI1 was found to be considerably less active than Prostaglandin E1 (PGE1). © 1983, The Pharmaceutical Society of Japan. All rights reserved.