Blockade of distal nephron sodium transport attenuates pressure natriuresis in dogs

Abstract

The sodium excretory responses (UNa V) to acute changes in renal arterial pressure (RAP) during blockade of distal nephron sodium transport were evaluated in seven sodium-replete anesthetized dogs. The major distal sodium entry pathways were blocked by intrarenal infusion of amiloride (AM, 10−5 mol/L) and bendroflumethiazide (BZ, 10−6mol/L). Infusion of AM plus BZ caused slight increases in renal blood flow (RBF, 4.1±0.5 to 4.6±0.4 mL · min−1 · g−1; P