In-vivo molecular investigations of live tissues using diffracting sources

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Abstract

We present novel technologies based on reconstructions employing diffracting sources in fluorescent mode that resolve molecular function in deep tissues. To facilitate time-efficient three-dimensional reconstructions we have employed fast analytical solutions of the diffusion equation to allow for close to real-time volumetric imaging of fluorescent near-infrared beacons that activate (fluoresce) with high specificity in the presence of specific molecular targets.

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Ntziachristos, V., Ripoll, J., Graves, E., & Weissleder, R. (2002). In-vivo molecular investigations of live tissues using diffracting sources. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 2488, pp. 739–745). Springer Verlag. https://doi.org/10.1007/3-540-45786-0_91

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