Comparative analysis of antifungal properties in diverse extracts of Arcangelisia flava (L.)

Abstract

Background: Prolonged fungal infections, specifically those induced by Candida species, underscore the critical need to advance efficacious antifungal treatments. Objective: The present investigation examines the antifungal characteristics of A. flava (L.), emphasising the root extracts of A. flava, which contain abundant secondary metabolites such as berberine. Method: The preparation of root extracts of A. flava utilised solvents of diverse polarities. The antifungal activity of these extracts against C. albicans, C. glabrata, and C. krusei was evaluated. Determining the Minimum Inhibition Concentration (MIC) and Minimum Fungal Concentration (MFC) for these extracts underscores the significance of selecting an appropriate solvent when extracting bioactive compounds. Result: The dichloromethane extract exhibited notable effectiveness, specifically against C albicans and C. krusei, thus highlighting its potential as a highly potent antifungal substance. To develop targeted therapies and gain a more comprehensive understanding of the antifungal properties of these extracts, it is critical to refine and isolate their active constituents, as demonstrated by this study. Conclusion: The findings indicate that A. flava, specifically its dichloromethane extract, may have potential as a reservoir of innovative antifungal compounds. This study makes a valuable contribution to the broader endeavour of incorporating conventional medicinal plants into contemporary pharmacological practices, specifically focusing on their potential to combat fungal infections.