Detecting epithelial sodium channel (ENAC) protein levels as a biomarker of hypertension

Abstract

Epithelial Sodium Channel (ENaC) is a protein that plays a role in maintaining sodium levels in the body. ENaC protein is abundant in the intestines, lungs, and kidneys. ENaC protein levels were measured from specific locations where the kidneys would be a good source of sodium excretion associated with hypertension. ENaC protein is one of the biomarkers hypertension based on lifestyle because it is related to sodium intakes in the body. ENaC protein is a biomarker of hypertension because it plays a role in sodium ion transport in cells which is related to blood pressure levels. Most hypertension or high blood pressures are not diagnosed on time because they are asymptomatic and existing protocols are less effective. The method to detect ENaC protein has been developed and can be a solution to this problem. This review describes various methods to detect ENaC protein as a biomarker of hypertension.