Fixed Drug Eruption due to Dupilumab

Abstract

Drug-induced cutaneous allergic reactions are widely observed with various medications (1). Among the various drug eruptions, fixed drug eruption is a cell-mediated immunologic reaction connected to molecular structure (2), and is a known adverse cutaneous reaction of monoclonal antibodies against human diseases (3). Dupilumab, a humanized monoclonal antibody against the IL-4/IL-13 receptor, has shown high efficacy against atopic dermatitis (4). However, several cutaneous adverse allergic reactions have been reported. Here, we report a case presenting an unusual clinical manifestation: multiple fixed drug eruptions caused by dupilumab.