Continuous gas/liquid-liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

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Abstract

4-Fluoropyrazole systems may be prepared by a single, sequential telescoped two-step continuous gas/liquid-liquid/liquid flow process from diketone, fluorine gas and hydrazine starting materials. © 2011 Breen et al.

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Breen, J. R., Sandford, G., Yufit, D. S., Howard, J. A. K., Fray, J., & Bhairavi Patel. (2011). Continuous gas/liquid-liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination. Beilstein Journal of Organic Chemistry, 7, 1048–1054. https://doi.org/10.3762/bjoc.7.120

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