A Facile and Rapid Method for Synthesizing Indole–Chalcone Hybrids

Abstract

Indole–chalcone hybrids are a large group of compounds known for their excellent biological properties the help combat diverse pathogens. This study describes a rapid synthetic pathway for the synthesis of ten indole–chalcone hybrids, namely, 3(a–j), from 1-Boc-3-formylindole (1) and acetophenone derivatives (2), in a one-pot approach. This synthesis involved an initial condensation reaction and subsequent deprotection of the Boc group. 1H-NMR, 13C-NMR, and MS were used to elucidate the structures of the final compounds. Contrary to previous methods for the synthesis of indole–chalcone hybrids, this novel synthetic method, which involves using a Boc-protected indole via microwave-assisted synthesis, is advantageous because it is a one-pot approach, making it facile and rapid.