Síntese e caracterização de arcabouços de quitosana com agente antineoplásicos

Abstract

The controlled release system of drugs through the use of polymeric biomaterials compounds associated with antineoplastic action can be employed as an alternative treatment of neoplasms. Thus, this study had as ob-jective the synthesis and characterization of the systems of scaffolds of chitosan loaded with the antineo-plastic agent (1,4-naphthoquinone), whose release rate can be controlled by using a crosslinking agent such as sodium tripolyphosphate (TPP). The preparation method consisted of solubilizing the chitosan in acetic acid, drug addition, freezing, lyophilization and crosslinking TPP. All samples were characterized by X-Ray Diffraction (XRD), scanning electron microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), degree of swelling and enzymatic biodegradation. SEM showed the formation of interconnected pores with varying shapes and sizes in all the studied structures characterizing the formation of scaffolds. In EDS the presence of chemical elements characteristic of the chemical composition of each material was observed. However, the presence of sodium was observed which can be related to the neutralization agent used. The crosslinking of the scaffolds was confirmed by XRD and EDS which increased the enzymatic degradation rate in vitro in the same sample. The incorporation of the drug was confirmed by XRD, degree of swelling and EDS. Thus, it can be concluded that occurred the formation of crosslinked and non-crosslinked porous scaffolds with morphological and physicochemical properties that can contribute to the carrying of antineo-plastic drugs, being possible to control the degradation rate thereof and probable the release of the drug.