Polyhexanide and chlorhexidine loaded chitosan wound dressings

Abstract

Wounds may be caused by surgery, trauma, or as a result of diseases such as diabetes. The disruption of the skin/internal tissues and the contact with the external environment may lead to microbial infection. Wound dressings are capable of providing a protective barrier and accelerate the wound healing process [1]. Chitosan is one of the most promising materials for wound dressings, due to its good biocompatibility, low toxicity, haemostatic properties, antibacterial activity and biodegradability [2]. The main goal of this work is to produce chitosan-based hydrogels to be used as efficient and safe drug delivery platforms.