Determination of Characteristic Frequency for Identification of Hot Spots in Proteins

Abstract

Identification of hot spots or protein-target binding sites in proteins using resonant recognition model requires the knowledge of characteristic frequency. For a successful protein target interaction, both the protein and the target signals must share the same characteristic frequency. The common characteristic frequency of a functional group of proteins is determined from the consensus spectrum obtained using DFT. In this work an alternative approach for identification of characteristic frequency using power spectral density is described. The performance of the proposed method is observed to be better than the DFT-based approach and is illustrated using simulation examples.