Modeling Chronic Glycemic Exposure Variables as Correlates and Predictors of Microvascular Complications of Diabetes

Abstract

We are pleased to respond to the letter by Orchard et al. (1), especially since they first raised the following question: Do composite measures of chronic glycemia correlate or predict complications better than individual components? Orchard et al. reported evidence against the hypothesis, while we (2) reported evidence for the hypothesis. Having considered their suggestions, we offer an explanation for why their conclusions differed from ours. Orchard et al. (3) compared the fit from two models, one consisting …