Abstract
Background: The inflammasome generates IL-1 family proteins, but its role in neutrophils is poorly understood. Results: Neutrophils store key inflammasome components in distinct intracellular compartments and release IL-1- and IL-18, but not IL-1- or IL-33. Conclusion: Neutrophils store inflammasome components in intracellular compartments. Significance: Targeting the inflammasome in neutrophils represents a future anti-inflammatory strategy. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Bakele, M., Joos, M., Burdi, S., Allgaier, N., Pöschel, S., Fehrenbacher, B., … Hartl, D. (2014). Localization and functionality of the inflammasome in neutrophils. Journal of Biological Chemistry, 289(8), 5320–5329. https://doi.org/10.1074/jbc.M113.505636
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